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Buprenorphine (BUP) is an oripavine analgesic that is beneficial in the maintenance treatment of opiate-dependent individuals. Although BUP has been studied extensively, relatively little is known about norbuprenorphine (norBUP), a major dealkylated metabolite of BUP....

Nor fentanyl is a Fentanyl metabolite and a potent synthetic narcotic analgesic with a rapid onset and short duration of action. Historically it has been used to treat breakthrough pain and is commonly used as a pre-op pain reliever. ...

Normeperidine, a major metabolite of meperidine, is half as potent as meperidine as an analgesic but two to three times more potent as a convulsant....

O-Desmethyltramadol is an opioid analgesic and an active primary blood metabolite of the synthetic analgesic tramadol. O-Desmethyltramadol is the active component in the designer drug “Krypton”, which is marketed in many countries as a legal high....